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Browse Recruiting Trials |
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 With help from the ALS Association, NEALS provides up-to-date
information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both
interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people
in more natural environments.
NEALS sources this database from public information posted on clinicaltrials.gov and other
public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.
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Phase III Interventional Trials in ALS:
Phase II Interventional Trials in ALS:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
 Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Familial ALS |
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| 2. |
Randomized Double Blind Placebo Controlled Cross-Over Study of Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease and ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 3. |
A Phase IIb, Multi-National, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) (BENEFIT-ALS) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 4. |
Study NOG112264, a Phase II Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 5. |
The Experimental Treatment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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Other Interventional Trials:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 2. |
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 3. |
Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS |
Active, currently recruiting |
Familial ALS |
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| 4. |
A Randomized Crossover Study of Standard, Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in Amyotrophic Lateral Sclerosis (ALS) Patients |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 5. |
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP) |
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| 6. |
Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS, Other: Assessment of Care |
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| 7. |
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 8. |
Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 9. |
A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS) |
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| 10. |
HDE Post-Approval Study (PAS) of NeuRx DPS for ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS) |
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| 11. |
Intra-spinal Cord Delivery of Human Neural Stem Cells in ALS Patients: Proposal for a Phase I Study |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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Observational Studies:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
Pre-familial Amyotrophic Lateral Sclerosis (Pre-fALS) study |
Active, currently recruiting |
Healthy Volunteer with a Family History of ALS |
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| 2. |
Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS |
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| 3. |
Non-Invasive Measurement of GI Motility in Patients With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer |
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| 4. |
Familial Amyotrophic Lateral Sclerosis (FALS) Study |
Active, currently recruiting |
Healthy Volunteer with a Family History of ALS |
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| 5. |
ALS Tissue Donation Program |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 6. |
Quantitative Measurement of Nutritional Substrate Utilization in Patients With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 7. |
EEG-Based Brain-Computer Interface Project for Individuals With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 8. |
Family Studies in Neuromuscular Disorders |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 9. |
PRISM Registry: Pseudobulbar Affect Registry Series |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 10. |
Collection of Blood Samples for DNA Analysis in Motor Neuron Diseases |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS) |
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| 11. |
Discovery and Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-02) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 12. |
Clinical and Molecular Manifestations of Inherited Neurological Disorders |
Active, currently recruiting |
Familial ALS |
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| 13. |
UW/VA Madison Brain Bank |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 14. |
Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 15. |
Screening and Natural History: Primary Lateral Sclerosis and Related Disorders |
Active, currently recruiting |
Primary Lateral Sclerosis (PLS) |
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| 16. |
Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression |
Active, currently recruiting |
Primary Lateral Sclerosis (PLS) |
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| 17. |
DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 18. |
Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS) |
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| 19. |
Skin Biopsies for Research in Motor Neuron Diseases |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 20. |
Analysis of Immune Activation in the Peripheral Blood of Patients with ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 21. |
The National Amyotrophic Lateral Sclerosis Registry |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 22. |
Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 23. |
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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