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Basic Trial Search

With help from the ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.

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Please fill out any combination of the fields below. Making a selection in each field is not required
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Trial Factors:
Disease:
Amyotrophic Lateral Sclerosis (ALS)
Sporadic ALS
Familial ALS
Primary Lateral Sclerosis (PLS)
Hereditary Spastic Paraplegia (HSP)
Healthy Volunteer
Healthy Volunteer with a Family History of ALS

Trial Category:
Any
Drug Trial
Stem cell trial
Nutrition
Biomarkers/imaging
Gene Therapy
Epidemiology (risk factor)
Device
Other

Trial Status:
Active, not yet recruiting
Active, currently recruiting
Active, Recruiting healthy subjects only
Active, no longer recruiting
Enrolling by Invitation
Closed

Trial Phase:
Phase 0
Phase I
Phase II
Phase III
Phase IV
Not Applicable

Type of Trial:
Interventional Trial
	with active agents/drugs only
	with active agents/drugs & a placebo
Observational Study

Date Trial Posted:
All
Within the last month
Within the 6 months
Within the last year

Date Trial last updated:

All

Within the last month

Within the 6 months

Within the last year

Location:

Nearby, Enter Zip Code:

Within:
20 miles 40 miles 100 miles 300 miles

Riluzole Use:

Only show studies that allow for Riluzole use

Eligibility Factors:

Gender

Male Female

Your Age

Vital Capacity

Enter FVC Score (% predicated normal):

Time since Symptom Onset:

Less than 12 months

Less than 18 months

Less than 24 months

Less than 36 months

More than 36 months

Not applicable

Time since Diagnosis:

Less than 12 months

Less than 18 months

Less than 24 months

Less than 36 months

More than 36 months

Not applicable

Click here to view or modify your search parameters.

Sporadic ALS- disease occurs at random with no clearly associated risk factors; most common form of ALS, affects approximately 90-95% ALS cases.

Familial ALS- ALS cases are inherited from 2 or more family members, affects 5-10% of ALS cases.

Trial Phase- objectives are different for each phase of a trial.

Phase I, drug is given to a small number of people to see if it is safe.
Phase II begins to look at effectiveness of the drug.
Phase III is considered the definitive test of whether a drug is effective, held at multiple research sites and much larger than the previous phases.

Interventional trial- study where exposure, for example a drug, is assigned; used to determine the effectiveness of a treatment or intervention.

With drugs and a placebo- One group gets the active treatment, the other gets the placebo. Everything else is held the same between the two groups, so that any difference in their outcome can be attributed to the active treatment.

Observational study- study in which patients are observed and where no treatment is given; researcher has no control over the experiment because they are done in a more natural setting than an interventional trial.

Vital Capacity- the maximum amount of air that can be expelled from the lungs after a maximum drawing of air into the lungs, measured by a spirometer and then scored as a percentage.

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